COMRADES 

The objectives of WP0 are to continuously monitor and provide means for the ComRaDes partners to share their knowledge within the consortium and to integrate the research activities as well as to communicate and disseminate the results to the scientific community and to the wider audience. WP0 will also carry out an efficient project management adapted to the specificities of ComRaDes.

This work-package will also monitor the IPR activities as well as the data management The WP1 has three objectives that are to provide a generic CFD-CRD framework for gassed fermenters with multiple impellers, to derive a rational scale-up / scale-down route and finally to design a scaled-down lab-scale’ fermenter’ that mimics the industrial life of micro-organisms. The goal of the WP2 is to obtain quantitative information on the impact of the oxygen and power dissipation gradients of the large-scale bioreactor on the physiology and performance of P. chrysogenum. The WP3 will provide a sound experimental data basis for realistically mirroring the metabolic and transcriptional responses on large-scale conditions of P. chrysogenum and S. cerevisiae (in cooperation with WPs 2, 4) and will derive data driven models (in cooperation with WP1). The main goal of this WP4 is to highlight the impact of bioreactor heterogeneity (i.e., driving the environmental fluctuations perceived at the single cell level) on microbial population phenotypic diversity (i.e. driven by biological noise).