Computation for Rational Design: From Lab to Production with Success


The work-package distribution among partners is described in this Figure

The objectives of WP0 are to continuously monitor and provide means for the ComRaDes partners to share their knowledge within the consortium and to integrate the research activities as well as to communicate and disseminate the results to the scientific community and to the wider audience. WP0 will also carry out an efficient project management adapted to the specificities of ComRaDes.

This work-package will also monitor the IPR activities as well as the data management The WP1 has three objectives that are to provide a generic CFD-CRD framework for gassed fermenters with multiple impellers, to derive a rational scale-up / scale-down route and finally to design a scaled-down lab-scale’ fermenter’ that mimics the industrial life of micro-organisms.The goal of the WP2 is to obtain quantitative information on the impact of the oxygen and power dissipation gradients of the large-scale bioreactor on the physiology and performance of P. chrysogenum.The WP3 will provide a sound experimental data basis for realistically mirroring the metabolic and transcriptional responses on large-scale conditions of P. chrysogenum and S. cerevisiae (in cooperation with WPs 2, 4) and will derive data driven models (in cooperation with WP1).The main goal of this WP4 is to highlight the impact of bioreactor heterogeneity (i.e., driving the environmental fluctuations perceived at the single cell level) on microbial population phenotypic diversity (i.e. driven by biological noise).


of the elements that will be developedand integrated

1 – Detailed analysis of the large-scale conditions, characterizing       the dynamic environment witnessed by the microorganisms.

2 – As precise as possible translation of this environment to the         lab-scale, via design of scale-down simulators.3 – Tests at lab-scale under conditions representative for large-          scale to find better combinations of strains and                                environmental conditions.4 – Back-translation of successful findings (e.g. more robust                strains, less variable environments) to the large-scale.

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Kick-off meeting october 12 2018 at DSM research center

Kick-off meeting october 12 2018 at DSM research center

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– computational analysis (TRL3) of two bioprocesses in large-scale fermenters combining existing fluid and reaction dynamics sub-models, – use of the computational framework to design scale-down simulators (TRL3), – computation-driven[…]

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Our Team

Prof Henk Noorman

Senior researcher at DSMPart-time of professo at TUDelft


Prof Ralf Takors

University of Stuttgart Institute of Biochemical Engineering

Tel.: 0049 71168564535
Mobile: 0049 68565164
Fax: 0049 68565164

Prof Frank Delvigne

University of LiègeTerra research center

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Dr Philippe Gabant


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Dr Emile van de Sandt

DSM Sinochem Pharmaceuticals
Operations & Technology

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Walter Van Gulik

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